1,-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (methyl CCNU) and adriamycin combination therapy
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منابع مشابه
Potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by amphotericin B in murine ependymoblastoma.
This paper reports the potentiation of the therapeutic effect of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) by amphotericin B (AMB) in s.c. transplanted murine ependymoblastoma 01B111. The rate of 2-month cures was 6% when tumors were treated 10 to 12 days after transplantation by a single 6 i.m. injection of 2.5 mg of CCNU per kg and reached 15% with 10 mg of CCNU per kg. When 25 mg o...
متن کاملIn Vivo Potentiation of 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea by the Radiation Sensitizer Benznidazole1
Recent studies in mouse tumor systems have indicated a potential therapeutic advantage in combining the radiosensitizer misonidazole (MISO) with cancer chemotherapy drugs. One agent the antitumor activity of which has been enhanced to a greater extent than its hematological or gastrointestinal toxicities is the nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-1nitrosourea (CCNU). Recently, sensitize...
متن کاملClinical studies with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037).
SUMMARY The clinical tolerance to 1.(2-chioroethyl)-3-cyclohexyl-1-nitro.sourea was explored in patients with advanced cancer. This compound is related to 1,3-bis(2-chloroethyl)-1-nitro sourea, an agent of recognized antineoplastic effectiveness, but has only one chloroethyl group, is more lipid soluble, and is at least as active or more active against mouse Leukemia 12 10. A single p.o. dose o...
متن کاملIn vivo potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by the radiation sensitizer benznidazole.
Recent studies in mouse tumor systems have indicated a potential therapeutic advantage in combining the radiosensitizer misonidazole (MISO) with cancer chemotherapy drugs. One agent the antitumor activity of which has been enhanced to a greater extent than its hematological or gastrointestinal toxicities is the nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU). Recently, sensitiz...
متن کاملSequential 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037) and 5-fluorouracil (NSC 19893) therapy of gastrointestinal cancer.
Thirty-six patients with advanced gastrointestinal carcinoma were treated sequentially with full therapeutic doses of l-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea followed by 5-fluorouracil. 5-Fluorouracil could be safely administered at 6 weeks although patients still demonstrated peripheral hematological depression secondary to the earlier l-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea therapy....
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ژورنال
عنوان ژورنال: Cancer
سال: 1974
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(197411)34:5<1593::aid-cncr2820340505>3.0.co;2-1